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1

Modeling Human Cytochrome P450 2D6 Metabolism and Drug-Drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines

Scheer, N., Kapelyukh, Y., McEwan, J., Beuger, V., Stanley, L. A., Rode, A., Wolf, C. R.

Journal:

Molecular Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.28 MB

english, 2012

2

In Vivo Responses of the Human and Murine Pregnane X Receptor to Dexamethasone in Mice

Scheer, N., Ross, J., Kapelyukh, Y., Rode, A., Wolf, C. R.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 1.71 MB

english, 2010

3

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

Hasegawa, M., Kapelyukh, Y., Tahara, H., Seibler, J., Rode, A., Krueger, S., Lee, D. N., Wolf, C. R., Scheer, N.

Journal:

Molecular Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.56 MB

english, 2011

4

A Role for Cytochrome b5 in the In Vivo Disposition of Anticancer and Cytochrome P450 Probe Drugs in Mice

Henderson, C. J., McLaughlin, L. A., Finn, R. D., Ronseaux, S., Kapelyukh, Y., Wolf, C. R.

Journal:

Drug Metabolism and Disposition

Year:

2013

Language:

english

File:

PDF, 948 KB

english, 2013

5

Investigations with a humanised CYP3A4/3A7 mouse model

Doyle, Eddie, Coutant, Anne-Laure, Kapelyukh, Yury, Boulenc, Xavier

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 88 KB

english, 2014

6

Generation and Characterization of Novel Cytochrome P450 Cyp2c Gene Cluster Knockout and CYP2C9 Humanized Mouse Lines

Scheer, N., Kapelyukh, Y., Chatham, L., Rode, A., Buechel, S., Wolf, C. R.

Journal:

Molecular Pharmacology

Year:

2012

Language:

english

File:

PDF, 432 KB

english, 2012

7

Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules

Kapelyukh, Y., Paine, M. J. I., Marechal, J.-D., Sutcliffe, M. J., Wolf, C. R., Roberts, G. C. K.

Journal:

Drug Metabolism and Disposition

Year:

2008

Language:

english

File:

PDF, 361 KB

english, 2008

8

Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model

Scheer, N., Kapelyukh, Y., Rode, A., Oswald, S., Busch, D., McLaughlin, L. A., Lin, D., Henderson, C. J., Wolf, C. R.

Journal:

Drug Metabolism and Disposition

Year:

2015

Language:

english

File:

PDF, 1.29 MB

english, 2015

9

The application of knockout and humanized models to study human pathways of anti-cancer drug metabolism

Roland Wolf, C., Kenneth MacLeod, A., Lin, De, Scheer, Nico, Kapelyukh, Yury, Henderson, Colin

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 62 KB

english, 2017

10

An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials

Henderson, Colin James, Kapelyukh, Yury, Scheer, Nico, Rode, Anja, McLaren, Aileen W, MacLeod, Alastair Kenneth, Lin, De, Wright, Jayne, Stanley, Lesley, Wolf, C Roland

Journal:

Drug Metabolism and Disposition

Year:

2019

Language:

english

File:

PDF, 1.32 MB

english, 2019

11

Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice

Kapelyukh, Yury, Henderson, Colin James, Scheer, Nico, Rode, Anja, Wolf, Charles Roland

Journal:

Drug Metabolism and Disposition

Year:

2019

Language:

english

File:

PDF, 1.93 MB

english, 2019